CV

Nicole M Iverson
Massachusetts Institute of Technology
77 Massachusetts Avenue
Department of Biological Engineering
Room 56-670
Cambridge, MA 02139
niverson@mit.edu

EDUCATION:

Rutgers University and University of Medicine and Dentistry of New Jersey
Ph. D. in Biomedical Engineering                                                            2010
M.S. in Biomedical Engineering                                                               2005

University of Minnesota, Institute of Technology
B.S. in Biomedical Engineering                                                                2003
Minors in Mathematics and Chemistry
Institute of Technology Honors

HONORS AND AWARDS:

Massachusetts Institute of Technology

• Listed on CNN’s Top Ten Ideas
• NIH Postdoctoral Fellowship
• Center for Environmental Health Sciences poster competition award
• MIT Post Doctorate Association poster competition award
• Aspen Cancer Conference, invited participant
• MIT Biological Engineering Retreat, invited participant
• Articles describing novel in vivo sensor NanotechWeb, Neue Zuricher Zeitung, MIT News
• Incorporation of sensor technology into exhibit, MIT Museum

Rutgers University

• American Heart Association Fellowship
• NIH Biotechnology Fellowship
• GAANN Fellowship
• Whitaker Foundation Fellowship

University of Minnesota

• Lillehei Heart Association Grant
• National Merit Scholarship
• Iron Range Scholarship
• American Heart Association Grant

RESEARCH EXPERIENCE:

Massachusetts Institute of Technology                                2010 – present
NIH Post Doctoral Fellow
Advisers: John Essigmann, Gerald Wogan, and Michael Strano

• Delivery, monitoring and analysis of in vivo nanoparticles that act as biological sensor
• Encapsulate, optimize and analyze DNA wrapped single wall carbon nanotubes in alginate microparticles
• Modified chemical structure of nanoparticle to enable non-invasive, intravenous delivery
• Spearheaded NIH grant writing effort
• Trained students and peers in proper in vivo techniques

Rutgers University                                                                    2003 – 2010
NIH Research Fellow
Advisers: Prabhas V. Moghe, Kathryn E. Uhrich, Gary B. Nackman
Graduate Thesis:  Multifunctional Nanoassemblies that Increase Highly Oxidized LDL Efflux while Inhibiting Highly Oxidized LDL Uptake, Cytokine Signaling and Matrix Metalloproteinase Activation

• Developed protocol and independently perform animal study to test the in vitro findings in an in vivo model
• Tested and analyzed biological effects of anionic nanoparticles on a cultured cell line with multiple biochemical, genetic, and fluorometric assays
• Designed and implemented RT²-PCR and PCR microarray based gene expression studies; specifically, analyzed atherosclerotic and inflammatory pathways
• Synthesized, purified and analyzed multifaceted nanoparticles
• Trained new students in proper lab technique and testing procedures
• Assist in writing grants for NSF, NIH and AHA

Mayo Clinic, Rochester, MN                                                                  2006
Research Internship
Adviser: Gary C Sieck

• Established protocol and mastered technique to label and capture different cell types with laser capture microdissection
• Mastered quantitative RT-PCR procedure and analysis

University of Minnesota                                                            2002 – 2003
Research Assistant
Adviser: Jay Zhang

• Observed and assisted with live animal operations for multiple protocols
• Researched and tested new techniques of stem cell delivery through a fibrinogen patch into the heart
• Interpreted data and wrote papers to explain the research for submission as journal articles
• Cultured cells from research animal

University of Minnesota                                                                       2001
Research Assistant
Adviser: Natalia Tretyakova

• Formulated and customized interstrand DNA cross-linking methods with multiple carcinogenic agents
• Optimized digestion methods for different compounds
• Created and ran gel electrophoresis and MALDI-TOF samples to determine DNA sequences and carcinogenic interference points

Fairview University Hospital, Pharmacy, Minneapolis, MN                  2000
Pharmaceutical Assistant
Adviser: Kathy Johnson

• Maintained accurate counts and labeling of drug quantities and distribution of pharmaceutical products in double blind clinical trials

Hennepin County Medical Center, Minneapolis, MN                            1999
Student Observer
Adviser: Timothy Henry

• Observed human subjects and assisted medical professionals with multiple medical procedures and experimental protocols to investigate cardiac catheterization treatments

TEACHING EXPERIENCE:

Rutgers University                                                                               2008
Pre-Calculus Instructor

• Created class syllabus, lesson plans and testing material
• Instructed and advised 30 students in lecture setting as well as one on one and small group sessions

University of Minnesota Talented Youth Math Program          2000 – 2002
Teaching Assistant – Algebra I and II

• Facilitated study sessions and provided personal assistance for students
• Evaluated and recorded weekly homework and quiz results
• Conducted weekly quizzes and examinations

PUBLICATIONS:

Landry MP, Kruss S, Nelson JT, Bisker G, Iverson NM, Reuel NF, Strano MS, Experimental Tools to Study Molecular Recognition within the Nanoparticle Corona. Sensors 2014 14(9):16196-16211.

Ulissi ZW, Sen F, Gong X, Sen S, Iverson NM, Boghossian A, Godoy L, Wogan GN, Mukhopadhyay, Strano MS, Spatiotemporal Intracellular Nitric Oxide Signaling Captured using Internalized, Near Infrared Fluorescent Carbon Nanotube Nanosensors. Nano Letters. 2014 14(8):4887-4894.

Bisker G, Iverson NM, Ahn J, Strano MS, A Pharmacokinetic Model of a Tissue Implantable Insulin Sensor. Advanced Healthcare Materials. Advanced Healthcare Materials. 2014.

Giraldo JP, Landry MP, Faltermeier S, McNicholas TP, Iverson NM, Boghossian AA, Reuel NF, Hilmer AJ, Sen F, Brew J, Strano MS, A nanobionic approach to augment plant photosynthesis and biochemical sensing using targeted nanoparticles. Nature Materials 2014 13(4):400-408.

Iverson NM, Barone PW, Shandell M, Trudell LJ, Sen S, Sen F, Ivanov V, Atolia E, Farias E, McNicholas TP, Reuel N, Parry NMA, Wogan GN, Strano MS, In Vivo biosensing via tissue localizable near infrared fluorescent single walled carbon nanotubes. Nature Nanotechnology 2013 8(11):873-880.

Iverson NM, Plourde NM, Sparks SM, Wang J, Patel EN, Shah PS, Lewis DR, Zablocki KR, Nackman GB, Uhrich KE, Moghe PV, Dual use of amphiphillic macromolecules as cholesterol efflux triggers and inhibitors of macrophage athero-inflammation. Biomaterials 2011 32(32):8319-8327.

Iverson NM, Sparks SM, Demirdirek B, Uhrich KE, Moghe PV, Controllable inhibition of cellular uptake of oxidized low density lipoprotein: structure-function relationships for nanoscale amphiphillic polymers. Acta Biomaterials 2010 6(8):3081-3091.

Iverson N, Plourde N, Chnari E, Nackman G, Moghe PV, Convergence of nanotechnology and cardiovascular medicine: progress and emerging prospects. BioDrugs 2008 22(1):1-10.

Wang J, Plourde N, Iverson N, Moghe PV, Uhrich KE, Nanoscale amphiphillic macromolecules as lipoprotein inhibitors: the role of charge and architecture. International Journal of Nanomedicine 2007 2(4):697-705.

Zhang J, Gong G, Ye Y, Guo T, Mansoor A, Hu Q, Ochiai K, Liu J, Wang X, Cheng Y, Iverson N, Lee J, From AH, Ugurbil K, Bache RJ. Nitric oxide regulation of myocardial O₂ consumption and HEP metabolism. American Journal of Physiology, Heart and Circulatory Physiology 2005 288(1):H310-H316.

PATENTS:

Iverson NM, Strano MS, Reuel NF, McNicholas TP. Near Infrared Fluorescent Single Walled Carbon Nanotubes as Tissue Localizable Biosensors. 61/878,303 Filing Date: Sept. 16 2013.

Uhrich KE, Moghe PV, Sparks S, Hehir S, Gu L, Iverson N, Plourde N. Polymeric Micelles for Reducing LDL In Vivo. US 20120219598 A1. Publication Date: Aug. 30 2012.

Moghe PV, Uhrich KE, Iverson N, Plourde N, Wang JZ. Compositions and Methods for Treating Cardiovascular Conditions. US20110008396 A1. Publication Date: Jan. 13 2011.

CONFERENCE PROCEEDINGS AND PRESENTATIONS:

Nicole M Iverson, Carbon Nanotubes as In Vivo Nitric Oxide Sensors. Massachusetts Institute of Technology Biological Engineering Retreat 2013.

Nicole M Iverson, Paul W Barone, Mia Shandell, Laura J Trudel, Selda Sen, Fatih Sen, Vsevolod Ivanov, Esha Atolia, Edgardo Farias, Thomas P McNicholas, Nigel Reuel, Nicola M A Parry, Gerald N Wogan and Michael S Strano, In Vivo Utilization of Near Infrared Fluorescent Single Walled Carbon Nanotubes as Tissue Localizable Biosensors. Aspen Cancer Conference 2013.

Nicole M Iverson, Paul W Barone, Mia Shandell, Laura J Trudel, Selda Sen, Fatih Sen, Vsevolod Ivanov, Esha Atolia, Edgardo Farias, Thomas P McNicholas, Nigel Reuel, Nicola M A Parry, Gerald N Wogan and Michael S Strano, In Vivo Utilization of Near Infrared Fluorescent Single Walled Carbon Nanotubes as Tissue Localizable Biosensors. Massachusetts Institute of Technology Center for Environmental Health Sciences Meeting 2013.

Nicole M Iverson, In Vivo Delivery of Single-Walled Carbon Nanotubes Acting as Nitric Oxide Sensors. DNA Repair and Mutagenesis Seminar 2013.

Nicole M Iverson, Paul W Barone, Mia Shandell, Laura J Trudel, Selda Sen, Fatih Sen, Vsevolod Ivanov, Esha Atolia, Edgardo Farias, Thomas P McNicholas, Nigel Reuel, Nicola M A Parry, Gerald N Wogan and Michael S Strano, In Vivo Utilization of Near Infrared Fluorescent Single Walled Carbon Nanotubes as Tissue Localizable Biosensors. Massachusetts Institute of Technology Post Doctorate Association Meeting 2013.

Nicole Iverson, Nicole Plourde, Sarah Sparks, Jinzhong Wang, Dr. Kathryn Uhrich and Prabhas V Moghe, Nanoscale Assembled Polymers for Nuclear Targeted Biomolecular Delivery in Macrophages: Multifunctional Biomaterial Candidates for Management of Atherosclerosis. Society of Biomaterials 2009.

Nicole Iverson, Nicole Plourde, Jinzhong Wang, Sarah Sparks, Dr. Kathryn Uhrich and Prabhas V Moghe, Bifunctional Nanoparticles Targeting Cells Leading to the Progression of Inflammation. Biomedical Engineering Society 2008.

Nicole Iverson, Nicole Plourde, Jinzhong Wang, Dr. Kathryn Uhrich and Prabhas V Moghe, Bifunctional Nanoparticles Targeting Scavenger Receptors and Nuclear Receptors. Biomedical Engineering Society 2007.

Nicole Iverson, Nicole Plourde, Jinzhong Wang, Dr. Kathryn Uhrich and Prabhas V Moghe, Design of Nanoparticles for Scavenger Receptor-Targeted Inhibition of Low Density Lipoproteins. Biomedical Engineering Society 2006.

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